August 8, 2024

Steve Forte
Chief Financial Officer
Repare Therapeutics Inc.
7171 Frederick-Banting, Building 2, Suite 270
St-Laurent, Qu  bec, Canada H4S 1Z9

       Re: Repare Therapeutics Inc.
           Registration Statement on Form S-3
           Filed August 6, 2024
           File No. 333-281298
Dear Steve Forte:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

       Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you that
the company and its management are responsible for the accuracy and adequacy of
their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Jessica Dickerson at 202-551-8013 with any questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Life
Sciences
cc:   Courtney Thorne, Esq.