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SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 4)*

REPARE THERAPEUTICS INC. (Name of Issuer)

Common Shares (Title of Class of Securities)

760273102 (CUSIP Number)

Ansbert Gadicke c/o MPM BioImpact LLC, 339 Boylston Street, Suite 1100 Boston, MA, 02116 617-425-9200 (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

12/20/2024 (Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person MPM BioVentures 2014, L.P.
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 1,731,575.00 8 Shared Voting Power 0.00 9 Sole Dispositive Power 1,731,575.00 10 Shared Dispositive Power 0.00
11	Aggregate amount beneficially owned by each reporting person 1,731,575.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 4.1 %
14	Type of Reporting Person (See Instructions) PN

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person MPM BioVentures 2014 (B), L.P.
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 115,492.00 8 Shared Voting Power 0.00 9 Sole Dispositive Power 115,492.00 10 Shared Dispositive Power 0.00
11	Aggregate amount beneficially owned by each reporting person 115,492.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 0.3 %
14	Type of Reporting Person (See Instructions) PN

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person MPM Asset Management Investors BV2014 LLC
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 59,603.00 8 Shared Voting Power 0.00 9 Sole Dispositive Power 59,603.00 10 Shared Dispositive Power 0.00
11	Aggregate amount beneficially owned by each reporting person 59,603.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 0.1 %
14	Type of Reporting Person (See Instructions) OO

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person UBS Oncology Impact Fund L.P.
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization CAYMAN ISLANDS
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 1,394,186.00 8 Shared Voting Power 0.00 9 Sole Dispositive Power 1,394,186.00 10 Shared Dispositive Power 0.00
11	Aggregate amount beneficially owned by each reporting person 1,394,186.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 3.3 %
14	Type of Reporting Person (See Instructions) PN

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person MPM BioVentures 2014 GP LLC
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 0.00 8 Shared Voting Power 1,847,067.00 9 Sole Dispositive Power 0.00 10 Shared Dispositive Power 1,847,067.00
11	Aggregate amount beneficially owned by each reporting person 1,847,067.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 4.3 %
14	Type of Reporting Person (See Instructions) OO

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person MPM BioVentures 2014 LLC
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 0.00 8 Shared Voting Power 1,906,670.00 9 Sole Dispositive Power 0.00 10 Shared Dispositive Power 1,906,670.00
11	Aggregate amount beneficially owned by each reporting person 1,906,670.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 4.5 %
14	Type of Reporting Person (See Instructions) OO

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person Oncology Impact Fund (Cayman) Management L.P.
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization CAYMAN ISLANDS
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 0.00 8 Shared Voting Power 1,394,186.00 9 Sole Dispositive Power 0.00 10 Shared Dispositive Power 1,394,186.00
11	Aggregate amount beneficially owned by each reporting person 1,394,186.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 3.3 %
14	Type of Reporting Person (See Instructions) PN

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person MPM BioImpact LLC
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 0.00 8 Shared Voting Power 1,394,186.00 9 Sole Dispositive Power 0.00 10 Shared Dispositive Power 1,394,186.00
11	Aggregate amount beneficially owned by each reporting person 1,394,186.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 3.3 %
14	Type of Reporting Person (See Instructions) OO

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person ANSBERT GADICKE
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 0.00 8 Shared Voting Power 3,300,856.00 9 Sole Dispositive Power 0.00 10 Shared Dispositive Power 3,300,856.00
11	Aggregate amount beneficially owned by each reporting person 3,300,856.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 7.8 %
14	Type of Reporting Person (See Instructions) IN

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person LUKE EVNIN
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 0.00 8 Shared Voting Power 1,906,670.00 9 Sole Dispositive Power 0.00 10 Shared Dispositive Power 1,906,670.00
11	Aggregate amount beneficially owned by each reporting person 0.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 4.5 %
14	Type of Reporting Person (See Instructions) IN

Comment for Type of Reporting Person:

0

SCHEDULE 13D

CUSIP No.

760273102

1	Name of reporting person Todd Foley
2	Check the appropriate box if a member of a Group (See Instructions)   (a)   (b)
3	SEC use only
4	Source of funds (See Instructions) WC
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)
6	Citizenship or place of organization UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:	7 Sole Voting Power 0.00 8 Shared Voting Power 1,906,670.00 9 Sole Dispositive Power 0.00 10 Shared Dispositive Power 1,906,670.00
11	Aggregate amount beneficially owned by each reporting person 1,906,670.00
12	Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)
13	Percent of class represented by amount in Row (11) 4.5 %
14	Type of Reporting Person (See Instructions) IN

SCHEDULE 13D

Item 1.	Security and Issuer
(a)	Title of Class of Securities: Common Shares
(b)	Name of Issuer: REPARE THERAPEUTICS INC.
(c)	Address of Issuer's Principal Executive Offices: 7171 FREDERICK BANTING, SUITE 270, BUILDING 2, SAINT-LAURENT, QUEBEC, CANADA , H4S 1Z9.
Item 1 Comment: Explanatory Note: This Amendment No. 4 to Schedule 13D ('Amendment No. 4') is being filed as an amendment to the initial statement on Schedule 13D relating to the common shares (the 'Common Shares'), of Repare Therapeutics Inc. (the 'Issuer'), as filed with the Securities and Exchange Commission (the 'SEC') on July 6, 2020, as amended by Amendment No. 1 filed March 23, 2021, Amendment No. 2 filed May 25, 2021 and Amendment No. 3 filed July 21, 2021 (as amended, the 'Original Schedule 13D'). This Schedule 13D/A is being filed by the Filing Persons to report the open market sales of the Issuer's Common Shares by certain Filing Persons. Items 2, 5 and 7 of the Original Schedule 13D are hereby amended and supplemented to the extent hereinafter expressly set forth and, except as amended and supplemented hereby, the Original Schedule 13D remains in full force and effect. All capitalized terms used in this Amendment No. 4 but not defined herein shall have the meanings ascribed thereto in the Original Schedule 13D.
Item 2.	Identity and Background
(a)	The entities and persons filing this statement are MPM BioVentures 2014, L.P. ('BV 2014'), MPM BioVentures 2014 (B), L.P. ('BV 2014(B)'), MPM Asset Management Investors BV2014 LLC ('AM BV2014 LLC'), UBS Oncology Impact Fund L.P. ('UBS Oncology'), MPM BioVentures 2014 GP LLC ('BV 2014 GP'), MPM BioVentures 2014 LLC ('BV 2014 LLC'), Oncology Impact Fund (Cayman) Management LP ('Oncology Cayman') and MPM BioImpact LLC ('BioImpact') (collectively, the 'MPM Entities') and Ansbert Gadicke, Luke Evnin and Todd Foley (collectively, the 'Listed Persons' and, together with the MPM Entities, the 'Filing Persons'). The Filing Persons expressly disclaim status as a 'group' for purposes of this Schedule 13D.
(b)	The address of the principal place of business for each of the MPM Entities and Ansbert Gadicke, Luke Evnin and Todd Foley is 399 Boylston Street, Suite 1100, Boston, MA 02116.
(c)	The principal business of each of the Filing Persons is the venture capital investment business.
(d)	During the last five years, none of the Filing Persons has been convicted in any criminal proceeding (excluding traffic violations or similar misdemeanors).
(e)	During the last five years, none of the Filing Persons has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree, or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.
(f)	Each of the Listed Persons is a United States citizen and each of the MPM Entities is a Delaware limited partnership or limited liability company, other than UBS Oncology and Oncology Cayman which are Cayman Islands limited partnerships. In accordance with the provisions of General Instruction C to Schedule 13D, information concerning the managers and each other person controlling the general partners of the MPM Entities required by Item 2 of Schedule 13D is listed on Schedule 1 to this Amendment No. 4 and is incorporated by reference herein.
Item 5.	Interest in Securities of the Issuer
(a)	See rows (11) and (13) of the Filing Persons Owner Profile of this Amendment No. 4 for the aggregate number of Common Shares and percentages of the shares of Common Shares beneficially owned by the Filing Person. The Common Shares are held as follows: • 1,731,575 shares are held directly by BV 2014; • 115,492 shares are held directly by BV 2014(B); • 59,603 shares are held directly by AM BV2014 LLC; and • 1,394,186 shares are held directly by UBS Oncology. BV 2014 GP and BV 2014 LLC are the direct and indirect general partners of BV 2014 and BV 2014(B) and, accordingly, may be deemed to beneficially own the shares held by BV 2014 and BV 2014(B). BV 2014 LLC is the managing member of AM BV2014 LLC and, accordingly, may be deemed to beneficially own the shares held by AM BV2014 LLC. BioImpact and Oncology Cayman are the direct and indirect general partners of UBS Oncology and, accordingly, may be deemed to beneficially own the shares held by UBS Oncology. Drs. Gadicke and Evnin and Mr. Foley are the managing directors of BV 2014 LLC and, accordingly, may be deemed to beneficially own the shares held by BV 2014, BV 2014(B) and AM BV2014 LLC. Dr. Gadicke is the managing partner of BioImpact and, accordingly may be deemed to beneficially own the shares held by UBS Oncology. Calculation of the percentage of the shares of Common Shares beneficially owned is based upon 42,510,708 share of Common Shares outstanding as of November 1, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 7, 2024.
(b)	See rows (7) through (10) of the Filing Persons Owner Profile of this Amendment No. 4 for the number of shares as to which there is sole power to vote or to direct the vote, sole power to dispose or to direct the disposition, or shared power to dispose or to direct the disposition.
(c)	The Reporting Persons sold the following Common Shares in the open market in the sixty days preceding the date of this filing: Date of Sale Price Range Ave. Price Sold by Sold by Sold By AM BV Sold by BV 2014 BV 2104(B) 2014 LLC UBS Oncology 12/13/24 $1.66-$2.01 $1.82 154,827 10,327 5,329 124,659 12/17/24 $1.45-$1.535 $1.48 13,565 905 466 10,922 12/18/24 $1.23-$1.33 $1.28 17,685 1,180 609 14,239 12/19/24 $1.265-$1.37 $1.33 31,717 2,115 1,092 25,537 12/20/24 $1.305-$1.45 $1.37 60,426 4,030 2,080 48,652 12/23/24 $1.27-$1.36 $1.32 26,894 1,794 925 21,654
(d)	Inapplicable.
(e)	Inapplicable.
Item 7.	Material to be Filed as Exhibits.
	Joint Filing Statement

SIGNATURE
	After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

MPM BioVentures 2014, L.P.

Signature: /s/ Ansbert Gadicke Name/Title: Managing Director of MPM BioVentures 2014 LLC, the Managing Member of MPM BioVentures 2014 GP LLC, the General Partner of MPM BioVentures 2014, L.P. Date: 12/26/2024

MPM BioVentures 2014 (B), L.P.

Signature: /s/ Ansbert Gadicke Name/Title: Managing Director of MPM BioVentures 2014 LLC, Managing Member of MPM BioVentures 2014 GP LLC, the General Partner of MPM BioVentures 2014 (B), L.P Date: 12/26/2024

MPM Asset Management Investors BV2014 LLC

Signature: /s/ Ansbert Gadicke Name/Title: Managing Director of MPM BioVentures 2014 LLC, the manager of MPM Asset Management Investors BV2014 LLC Date: 12/26/2024

UBS Oncology Impact Fund L.P.

Signature: /s/ Ansbert Gadicke Name/Title: Managing Partner of MPM BioImpact LLC, the GP of Oncology Impact Fund (Cayman) Management L.P., the GP of UBS Oncology Impact Fund L.P. Date: 12/26/2024

MPM BioVentures 2014 GP LLC

Signature: /s/ Ansbert Gadicke Name/Title: Managing Director of MPM BioVentures 2014 LLC, the Managing Member of MPM BioVentures 2014 GP LLC Date: 12/26/2024

MPM BioVentures 2014 LLC

Signature: /s/ Ansbert Gadicke Name/Title: Managing Director of MPM BioVentures 2014 LLC Date: 12/26/2024

Oncology Impact Fund (Cayman) Management L.P.

Signature: /s/ Ansbert Gadicke Name/Title: Managing Partner of MPM BioImpact LLC, the General Partner of Oncology Impact Fund (Cayman) Management L.P. Date: 12/26/2024

MPM BioImpact LLC

Signature: /s/ Ansbert Gadicke Name/Title: Managing Partner Date: 12/26/2024

ANSBERT GADICKE

Signature: /s/ Ansbert Gadicke Name/Title: Ansbert Gadicke Date: 12/26/2024

LUKE EVNIN

Signature: /s/ Luke Evnin Name/Title: Luke Evnin Date: 12/26/2024

Todd Foley

Signature: /s/ Todd Foley Name/Title: Todd Foley Date: 12/26/2024

Schedule I

 General Partners/Members

Ansbert Gadicke

c/o BioImpact

399 Boylston Street, Suite 1100

Boston, MA 02116

Principal Occupation: Managing director of MPM BioVentures 2014 LLC and managing partner of MPM BioImpact LLC.

Citizenship: USA

Luke Evnin

c/o BioImpact

399 Boylston Street, Suite 1100

Boston, MA 02116

Principal Occupation: Managing director of MPM BioVentures 2014 LLC.

Citizenship: USA

Todd Foley

c/o BioImpact

399 Boylston Street, Suite 1100

Boston, MA 02116

Principal Occupation: Managing director of MPM BioVentures 2014 LLC.

Citizenship: USA

Joint Filing Statement

I, the undersigned, hereby express my agreement that the attached Schedule 13D (and any amendments thereto) relating to the beneficial ownership by the undersigned of the equity securities of Repare Therapeutics Inc. is filed on behalf of each of the undersigned.

Date: December 26, 2024

MPM BIOVENTURES 2014, L.P.

By: MPM BioVentures 2014 GP LLC, its General Partner

By: MPM BioVentures 2014 LLC, Its Managing Member

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke

Title: Managing Director

MPM BIOVENTURES 2014 (B), L.P.

By: MPM BioVentures 2014 GP LLC, its General Partner

By: MPM BioVentures 2014 LLC, Its Managing Member

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke

Title: Managing Director

MPM ASSET MANAGEMENT INVESTORS BV 2014 LLC

By: MPM BioVentures 2014 LLC Its: Manager

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke

Title: Managing Director

MPM BIOVENTURES 2014 GP, LLC

By: MPM BioVentures 2014 LLC, Its Managing Member

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke

Title: Managing Director

MPM BIOVENTURES 2014 LLC

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke

Title: Managing Director

UBS ONCOLOGY IMPACT FUND, L.P.

By: Oncology Impact Fund (Cayman) Management L.P., its General Partner

By: MPM BioImpact LLC, Its General Partner

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke

Title: Managing Partner

ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P.

By: MPM BioImpact LLC, Its General Partner

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke

Title: Managing Partner

MPM BIOIMPACT LLC

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke

Title: Managing Partner

By:

/s/ Todd Foley

Name: Todd Foley

By:

/s/ Luke Evnin

Name: Luke Evnin

By:

/s/ Ansbert Gadicke

Name: Ansbert Gadicke