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Disclosure - Organization and Nature of Business - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100450 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100460 - Disclosure - Summary of Significant Accounting Policies - Schedule of Estimated Useful Lives of Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 100470 - Disclosure - Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 100480 - Disclosure - Fair Value Measurements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100490 - Disclosure - Cash and Cash Equivalents and Marketable Securities - Summary of Cash and Cash Equivalents and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 100500 - Disclosure - Cash and Cash Equivalents and Marketable Securities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100510 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 100520 - Disclosure - Property and Equipment, Net - Schedule of Depreciation Expense Recognized (Details) link:presentationLink link:calculationLink link:definitionLink 100530 - Disclosure - Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 100540 - Disclosure - License Agreements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100550 - Disclosure - Leases - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100560 - Disclosure - Leases - Summary of Lease Costs (Details) link:presentationLink link:calculationLink link:definitionLink 100570 - Disclosure - Leases - Summary of Other Operating Lease Information (Details) link:presentationLink link:calculationLink link:definitionLink 100580 - Disclosure - Leases - Summary of Future Minimum Lease Payments under Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 100590 - Disclosure - Convertible Preferred Shares - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100600 - Disclosure - Convertible Preferred Shares - Summary of Preferred Shares (Details) link:presentationLink link:calculationLink link:definitionLink 100610 - Disclosure - Shareholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100620 - Disclosure - Share-Based Compensation - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100630 - Disclosure - Share-Based Compensation - Schedule of Assumptions used to Determine Grant Date Fair Value under ESPP Offering (Details) link:presentationLink link:calculationLink link:definitionLink 100640 - Disclosure - Share-Based Compensation - Schedule of Fair Value of Stock Options Determined on Grant Date Using Black Scholes Option-Pricing Model (Details) link:presentationLink link:calculationLink link:definitionLink 100650 - Disclosure - Share-Based Compensation - Schedule of Share Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 100660 - Disclosure - Share-Based Compensation - Schedule of Share-based Compensation Expense for All Awards (Details) link:presentationLink link:calculationLink link:definitionLink 100670 - Disclosure - Share-Based Compensation - Schedule of Share-based Compensation Expense by Type of Award (Details) link:presentationLink link:calculationLink link:definitionLink 100680 - Disclosure - Employee Savings Plan - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100690 - Disclosure - Collaborations - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100700 - Disclosure - Collaborations - Schedule of Transaction Price Performance Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 100710 - Disclosure - Income Taxes - Summary of Loss Before Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 100720 - Disclosure - Income Taxes - Summary of provision for income taxes (Details) link:presentationLink link:calculationLink link:definitionLink 100730 - Disclosure - Income Taxes - Summary of Reconciliation of Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 100740 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100750 - Disclosure - Income Taxes - Summary of Losses Expire (Details) link:presentationLink link:calculationLink link:definitionLink 100760 - Disclosure - Income Taxes - Summary of Investment Tax Credits Expire (Details) link:presentationLink link:calculationLink link:definitionLink 100770 - Disclosure - Income Taxes - Summary of Deferred Tax Assets (Details) link:presentationLink link:calculationLink link:definitionLink 100780 - Disclosure - Net Loss per Share - Summary of Basic and Diluted Net Loss per Share Attributable to Common Stockholders (Details) link:presentationLink link:calculationLink link:definitionLink 100790 - Disclosure - Net Loss per Share - Computation of Diluted Net Loss Per Share in Attributable to Common Shareholders Indicate to Anti Diluted Effect (Details) link:presentationLink link:calculationLink link:definitionLink 100800 - Disclosure - Government Assistance - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100810 - Disclosure - Commitments and Contingencies - Schedule of Commitments to Settle Contractual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 100820 - Disclosure - Commitments and Contingencies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100830 - Disclosure - Currency Risk - Schedule of Financial Position Exposure (Details) link:presentationLink link:calculationLink link:definitionLink 100840 - Disclosure - Currency Risk - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100850 - Disclosure - Related Parties - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100860 - Disclosure - Geographic Information - Schedule of Property and Equipment, Net by Location (Details) link:presentationLink link:calculationLink link:definitionLink 100870 - Disclosure - Geographic Information - Schedule of Right-of-Use Assets by Location (Details) link:presentationLink link:calculationLink link:definitionLink 100880 - Disclosure - Geographic Information - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100890 - Disclosure - Subsequent Events - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink