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Lease Liabilities Contractual obligation per year Contractual Obligation Amount Per Year Contractual obligation amount per year. TOTAL LIABILITIES Liabilities Schedule Of Property Plant And Equipment [Table] Property, Plant and Equipment [Table] Cambridge, Massachusetts MASSACHUSETTS Foreign Currency Transaction Gain Loss Foreign currency transaction gain (loss). Foreign exchange loss (gain) Balance Balance Equity, Attributable to Parent TOTAL SHAREHOLDERS' EQUITY Documents Incorporated by Reference [Text Block] Documents Incorporated by Reference Net loss Percentage of liquidation rights waived by holder of preferred shares Percentage Of Liquidation Rights Waived By Holder Of Preferred Shares Percentage of liquidation rights waived by holder of preferred shares. Other income (expense), net Nonoperating Income (Expense) [Abstract] Standby Letters of Credit Standby Letters of Credit [Member] Upfront Non Refundable First Payment Received Upfront Non Refundable First Payment Received [Member] Upfront non refundable first payment received member. Cash and Cash Equivalents Cash and Cash Equivalents [Domain] Fair Value Measurements Fair Value Measurement, Policy [Policy Text Block] Statement of Financial Position [Abstract] Clinical Trial Materials [Member] Clinical Trial Materials [Member] Clinical Trial Materials [Member] Weighted-average number of common shares outstanding-diluted Weighted-average common shares outstanding-diluted Weighted Average Number of Shares Outstanding, Diluted Weighted Average Number of Shares Outstanding, Diluted, Total Contractual Obligation, to be Paid, after Year Five Following years Summary of Reconciliation of Provision for Income Taxes Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Impairment of long-lived assets Impairment of Long-Lived Assets to be Disposed of Credit Facility Credit Facility [Axis] Accrued Expenses and Other Current Liabilities Accrued Expense And Other Current Liabilities [Member] Accrued expense and other current liabilities. Shares issued, price per share Shares Issued, Price Per Share Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost Weighted-average remaining lease term (in years) Operating Lease, Weighted Average Remaining Lease Term Use of Estimates Use of Estimates, Policy [Policy Text Block] Income Taxes Income Tax Disclosure [Text Block] Operating lease liability Deferred Tax Assets Operating Lease Liability Deferred tax assets operating lease liability. Additional Clinical Development Plan [Member] Additional Clinical Development Plan [Member] Additional Clinical Development Plan [Member] Smaller Reporting Company Smaller Reporting Company Policy Text Block Smaller reporting company policy text block Weighted average exercise price, Outstanding at beginning of period Weighted average exercise price, Outstanding at end of period Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Percentage of depreciation USD against Canadian dollar Percentage Of Depreciation U S D Against Canadian Dollar Percentage of depreciation USD against Canadian dollar. Summary of Computation of Basic and Diluted Net Loss Per Share Attributable to Common Shareholders Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Leasehold Improvements Leasehold Improvements [Member] Completion of Continuing Trials Completion of Continuing Trials [Member] Completion of Continuing Trials [Member] Income Tax Authority Income Tax Authority [Axis] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Fair Value Disclosures [Abstract] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Axis] 2040 Investment Tax Credits Expire Four Investment tax credits expire four. Research Activities Research Activities [Member] Research activities. Measurement Frequency Measurement Frequency [Domain] 2038 Income Tax Losses Expire Six Income tax losses expire six. Payments to Acquire Property, Plant, and Equipment Payments to Acquire Property, Plant, and Equipment, Total Purchase of property and equipment Summary of Investment Tax Credits Expire Summary Of Investment Tax Credits Expire Table [Text Block] Summary of investment tax credits expire. Marketable securities Marketable Securities [Member] Marketable securities. Restricted stock units, Vested and released Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Shares issued Issuance of common shares, Shares Stock Issued During Period, Shares, New Issues Employee-related Liabilities, Current, Total Accrued compensation and benefits Employee-related Liabilities, Current Cash and cash equivalents at end of year Cash and cash equivalents cash at beginning of year Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total Deferred revenue, current Classified as short-term Deferred Revenue, Current Deferred Revenue, Current, Total Proceeds from Sale and Maturity of Marketable Securities, Total Proceeds from maturities of marketable securities Proceeds from Sale and Maturity of Marketable Securities Income Tax Disclosure [Abstract]