Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material Pursuant to § 240.14a-12

No fee required.

Fee paid previously with preliminary materials.

Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

P.O. BOX 8016, CARY, NC 27512-9903

Repare Therapeutics Inc.

Important Notice Regarding the Availability

of Proxy Materials

Shareholders Meeting to be held on

May 13, 2022

For Shareholders of record as of March 21, 2022

This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting. To appoint a third party proxyholder, a shareholder of record must return its proxy card by mail in accordance with the instructions provided in the proxy materials by no later than by 10:00 A.M., Eastern Time, on May 11, 2022.

To view the proxy materials, and to obtain directions to attend the meeting, go to: www.proxydocs.com/RPTX

To vote your proxy while visiting this site, you will need the 12 digit control number in the box below.

Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet.

For a convenient way to view proxy materials and VOTE go to www.proxydocs.com/RPTX

Have the 12 digit control number located in the shaded box above available

when you access the website and follow the instructions.

INTERNET

www.investorelections.com/RPTX

TELEPHONE

(866) 648-8133

* E-MAIL

[email protected]

When requesting via the Internet or telephone you will need the 12 digit control number located in the shaded box above.

* If requesting material by e-mail, please send a blank e-mail with the 12 digit control number (located above) in the subject line. No other requests, instructions OR other inquiries should be included with your e-mail requesting material.

Repare Therapeutics Inc.

Meeting Type: Annual Meeting of Shareholders

Date:  Friday, May 13, 2022

Time:  4:00 PM, Eastern Time

Place:  Annual Meeting to be held live via live webcast - please visit

             www.proxydocs.com/RPTX for more details.

             For information about this notice, please call (888) 464-5457.

You must pre-register to attend the meeting online and/or participate  at www.proxydocs.com/RPTX.

SEE REVERSE FOR FULL AGENDA

To elect three Class II directors to our Board of Directors, each to hold office until our Annual Meeting of Shareholders in 2025. The Board of Directors intends to present for election the following three current director nominees as Class II directors:

To approve, on a non-binding, advisory basis, the compensation of our named executive officers;

To recommend, on a non-binding, advisory basis, the preferred frequency of future advisory votes on compensation of our named executive officers;

To appoint Ernst & Young LLP as our independent registered public accounting firm (the “auditor”) for the fiscal year ending December 31, 2022, and to authorize the Board of Directors to fix the auditor’s remuneration; and

To conduct any other business properly brought before the Annual Meeting.